Innovative Model-based decision support systems for Personalised Anti-Coagulent Therapy for patients during Open Heart Surgeries

Heparin (anticoagulant) and protamine (binds heparin) are important medications to achieve a good balance of thrombosis and bleeding risk during open heart surgery. To keep a good balance for the patient is complex due to patient variability, increasing risks of thrombosis or bleeding. Current treatment guidelines hardly account for individual patient profiles, leading to suboptimal outcomes.