The industry in Top Sector HTSM consists of 86,000 enterprises employing 490,000 people, many of them in SME, start-ups and scale-ups. This industry creates 139 billion euros in production value, and 49 billion euros in export. It invests 4 billion euros in R&D annually, of which over 500 million euros in collaborative programs with academia and government, inside and outside the Netherlands.